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Blue Arc Home About Services Outcome Guide Safety & Risks Trials & Timeline Contact Blue Arc / outcome overview / revision 2026 Ibogaine Success Rate A careful way to separate acute withdrawal relief, short-term abstinence, longer-term recovery, and the safety conditions that shape each outcome. Scope: opioid use disorder Evidence: limited Safety: critical 01 / REFERENCE FRAME Define the outcome before using a number A single percentage cannot capture the different things people mean by success after ibogaine treatment. Several endpoints, different levels of certainty Ibogaine is a naturally occurring psychoactive alkaloid derived from the root bark of the Tabernanthe iboga plant, native to Central West Africa. The plant has a history of use among indigenous communities in Africa, while its use in western medicine remains experimental and contested. When people discuss addiction treatment, “success” may mean rapid relief of opioid withdrawal, reduced drug cravings, a period of abstinence, improved mental health, or sustained long-term sobriety. These are related outcomes, but they are not interchangeable. For people with substance use disorder, the detox process may be the first visible change. That does not establish durable recovery. Recovery also depends on individual needs, living conditions, psychiatric conditions, access to medical care, and a support system after treatment. Ibogaine is often described as a treatment initiator: it may create a window for deeper work, but it is not evidence of a permanent cure for addiction. A broad systematic review of clinical ibogaine evidence found a limited body of research studies, with relatively few randomized controlled trials and many open-label or observational reports. That limits how confidently any headline percentage can be generalized. FIG. A — OUTCOME MEASURES ARE NOT INTERCHANGEABLE 01 / Acute phase Withdrawal symptoms and the detoxification period. 02 / Early follow-up Changes in drug cravings, use, a

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